Human chorionic gonadotropin

hcg blood tests

Human chorionic gonadotropin, or hCG, is a hormone that is produced during pregnancy. It helps to control the functions of the corpus luteum and the placenta. hCG can also be used to treat infertility in women and men. In this blog post, we will discuss what you need to know about hCG, including its uses and side effects.

Function human chorionic gonadotropin

Human chorionic gonadotropin (hCG) acts as a ligand for the LHCG receptor in the ovary and helps to maintain the corpus luteum throughout pregnancy. This allows the corpus luteum to produce progesterone during the first trimester. During pregnancy, progesterone aids in the development of the uterine lining by increasing blood vessel and capillary density.

It’s been suggested that hCG might be a placenta link in the formation of local maternal immunotolerance. Endometrial cells treated with hCG induce apoptosis in T cells, for example. These findings indicate that hCG may be a link in the evolution of peritrophobastic immune tolerance, as well as assisting the trophoblast invasion, which is known to speed up fetal development in the endometrium. It has also been proposed that hCG levels are related to the severity of pregnancy sickness or Hyperemesis gravidarum.

hCG can also be used clinically to induce ovulation in the ovaries and testosterone production in the testes because of its resemblance to LH. Because pregnant women have by far the most plentiful biological source, some organizations collect urine from pregnant women to extract hCG for use in infertility therapy.

Human chorionic gonadotropin (hCG) can stimulate cell differentiation and multiplication, as well as apoptosis.

Form human chorionic gonadotropin

Humans make three types of hCG, each with a distinct physiological function. These include normal hCG, hyperglycosylated hCG, and the free beta-subunit of hCG. nicked hCG, which lacks the C-terminal peptide from the beta-subunit, and free alpha-subunit, which has no known biological role, are degradation products of hCG. The pituitary gland also produces small amounts of hCG that have a glycosylation pattern different from that found in placenta-derived forms of hCG.

The most common type of hCG is short-chain ultrafine (also known as “ultrafine” or “microspheres”). It’s produced in the placenta’s trophoblast cells. The main form of hCG during pregnancy is hyperglycosylated hCG, which can be found in invasive molar pregnancies and choriocarcinoma.

For pharmaceutical usage, human chorionic gonadotropin (HCG) preparations may be manufactured from animal or synthetic sources. Some of them are medically necessary, while others are quackery.

Uses human chorionic gonadotropin

Human chorionic gonadotropin (hCG) is most commonly used to treat infertility in women and men. It can also be used as a form of injectable birth control.

Fertility

false positive hcg tests

Human chorionic gonadotropin (hCG) is a hormone that is used to induce final maturation in cattle and sheep. In the presence of one or more mature ovarian follicles, ovulation may be induced by HCG administration. Ovulation will happen between 38 and 40 hours after a single dose of hCG, allowing procedures like intrauterine insemination or sex to be scheduled based on this time sequence. In addition, IVF patients, in general, receive HCG to induce ovulation, but they have an oocyte retrieval performed approximately 34 to 36 hours after injection, a few hours before the eggs would otherwise be released from the ovary.

Administration of HCG, which helps the corpus luteum mature and produce more progesterone, is sometimes used to boost progesterone production in women with a damaged or absent corpus luteum.

HCG injections are used to stimulate Leydig cells in the male to produce testosterone. Intratesticular testosterone is required for spermatogenesis from the Sertoli cells. Hypogonadism and fertility therapy, including during testosterone replacement treatment to restore or maintain fertility and prevent testicular atrophy, are some of the typical applications for HCG in males.

There are several vaccines for hCG to prevent pregnancy currently in clinical testing.

Tumor marker

Human chorionic gonadotropin (hCG) can be used as a tumor marker since its β subunit is secreted by some cancers including seminoma, choriocarcinoma, germ cell tumors, hydatidiform mole, teratoma with features of choriocarcinoma, and islet cell tumor. As a result, positive findings in males might be an indication of testicular cancer. The typical range for males is 0-5 mIU/mL when measured alone. Germ cell tumors are effectively diagnosed using β-HCG combined with alpha-fetoprotein.

HCG Tubergen, Pregnyl warnings

pregnancy test

In the case of lady users who wish to be treated with HCG Pubergen, Pregnyl:

  • The drug has been shown in animal studies to cause tumors, and there are several human reports regarding its safety. In a small population of infertile women that undergo medically assisted reproduction (especially those who need IVF), including endometriosis, tubal abnormalities may be prevalent after treatment with this medication, resulting in many more ectopic conceptions. Because of this, early ultrasonographic confirmation of pregnancy (to determine whether the pregnancy is intrauterine or not) is critical. Multiple pregnancies have a greater chance after pregnancies induced by the drug. Patients who have thrombosis, are severely overweight, or suffer from thrombophilia should not take this medicine since they have an increased risk of arterial or venous thromboembolic events after or during a treatment with HCG Pubergen, Pregnyl.
  • Patients who have been given this medication are more likely to experience pregnancy losses.

In the case of male patients, a long course of HCG Pubergen, Pregnyl is associated with increased androgen production. As a result, persons who have overt or latent cardiac failure, hypertension, renal disease, migraines, or epilepsy might not be allowed to utilize this medication or require a lower dose of HCG Pubergen, Pregnyl. In order to minimize the danger of early sexual development or premature epiphyseal closure, this medication should be used with particular caution in treating prepubescent children. To ensure accurate skeletal maturation monitoring, this sort of patients’ growth must be closely and frequently observed.

The list of medical problems that prevent patients from beginning treatment with Pubergen, Pregnyl includes:

  • You had a negative reaction to this medicine or one of its main components.
  • Male breast carcinoma or prostatic carcinoma are two examples of well-known or possible androgen-dependent tumors.

Anabolic steroid adjunct

HCG is increasingly used in combination with a variety of anabolic-androgenic steroid (AAS) cycles in the world of performance-enhancing drugs. As a consequence, some sports’ banned drug lists include HCG.

When exogenous AAS are introduced into the male body, natural negative-feedback loops cause the hypothalamic-pituitary-gonadal axis to shut down testosterone production through the shutdown of the hypothalamic-pituitary-gonadal axis (HPGA). Testicular atrophy is one of the side effects. HCG is often used during and after steroid cycles to maintain and stimulate testicular growth while also maintaining normal testosterone levels.

AASs mimic the body’s natural testosterone and trigger the hypothalamus to shut down its production of gonadotropin-releasing hormone (GnRH) from the hypothalamus. The pituitary gland loses its ability to produce luteinizing hormone (LH) as a result of GnRH being shut off by the hypothalamus. Testosterone is normally made in the testes as a result of luteinizing hormone (LH) traveling via the bloodstream from the pituitary. Without LH, testosterone production in the testes will cease. In males, HCG stimulates LH and stimulates the production and release of testosterone by mimicking it. If HCG is administered for a long time or in a high dose, the increase in natural testosterone and estrogen eventually inhibits endogenous luteinizing hormone production via negative feedback on the hypothalamus and pituitary gland.

HCG has also been detected in previously drug-free professional athletes, such as a 50-game baseball suspension for Manny Ramirez in 2009 and a 4-game NFL ban for Brian Cushing in 2012 following an HCG positive urine test. Dennis Siver was fined $19,800 and suspended 9 months after failing a UFC 168 fight.

Homeopathic HCG for weight control

pregnancy tests

The use of homeopathic HCG for weight reduction has caused a lot of controversy and shortages because of the popularity of Internet claims about it. The components in these treatments are often obscure, but if manufactured via homeopathic dilution from genuine HCG, they usually include no or only tiny amounts of HCG. Furthermore, owing to the presence of digestive proteases and hepatic metabolism, peptide-based chemicals (such as insulin and human growth hormone) become biologically inactive. HCG can only enter the circulation via injection.

The United States Food and Drug Administration has stated that over-the-counter HCG products are a hoax and a failure for weight reduction. They have also been ruled illegal because they are not homeopathic medications and have been classified as drugs. In the United States, HCG is a prescription drug, and it has never received FDA approval for over-the-counter sales as a weight loss product or for any other purpose, thus neither pure HCG nor any preparations containing it may be sold outside of medical supervision. The FDA and FTC began to take action in December 2011 to remove unapproved HCG products from the market. In response, some manufacturers started using “hormone-free” versions of their weight loss solutions, replacing the hormone with a combination of free amino acids or radionics.

Side effect HCG

HCG injections can cause a number of side effects, including gynecomastia, testicular atrophy, and infertility. HCG increases the risk for ovarian hyperstimulation syndrome (OHSS) in women undergoing fertility treatments. OHSS is a potentially life-threatening condition that causes fluid to build up in the abdomen and chest. It occurs in about one percent of women who take hCG to stimulate ovulation.

Overall, HCG is an effective means of restoring endogenous testosterone production and spermatogenesis following long-term AAS administration or severe hypogonadism. When used appropriately, it can safely be part of post-cycle therapy to help reverse some of the negative consequences associated with steroid use while minimizing potential adverse effects.

Summary

The use of human chorionic gonadotropin (HCG) to restore the axis of the hypothalamic-pituitary-gonadal (HPG) axis in males after long-term anabolic-androgenic steroid (AAS) use or severe hypogonadism is a well-known, but underutilized therapy. HCG can be safely used as part of post-cycle therapy to help reverse some of the negative consequences associated with steroid use while minimizing potential adverse effects. HCG is also effective in restoring endogenous testosterone production and spermatogenesis following long-term AAS administration or severe hypogonadism. When used appropriately, it can be an important part of post-cycle therapy.

FAQ’s

Is chorionic gonadotropin the same as hCG?

No, chorionic gonadotropin (CG) and human chorionic gonadotropin (hCG) are not the same. HCG is a hormone that is produced by the placenta during pregnancy. CG is a peptide hormone that is secreted from the pituitary gland.

What are some of the side effects of HCG?

HCG injections can cause a number of side effects, including gynecomastia, testicular atrophy, and infertility. HCG increases the risk for ovarian hyperstimulation syndrome (OHSS) in women undergoing fertility treatments. OHSS is a potentially life-threatening condition that causes fluid to build up in the abdomen and chest. It occurs in about one percent of women who take hCG to stimulate ovulation.

Is HCG legal?

No, in the United States, HCG is a prescription drug, and it has never received FDA approval for over-the-counter sales as a weight loss product or for any other purpose. The FDA and FTC began to take action in December 2011 to remove unapproved HCG products from the market. In response, some manufacturers started using “hormone-free” versions of their weight loss solutions, replacing the hormone with a combination of free amino acids or radionics.

Do I need a prescription for HCG?

Yes, in order to purchase HCG injections in the United States, you will need a prescription from your doctor.

What is HCG used for?

HCG is a hormone that is produced in the body during pregnancy and early childhood development. It can also be used to increase testosterone levels and help reverse some of the negative consequences associated with steroid use, including decreased sperm count, testicular atrophy (shrinking), gynecomastia (enlarged breasts), erectile dysfunction, and low libido.

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